Last reviewed 2026-04-23 · How we verify

Adult Bone Marrow Stem Cells

Adult Bone Marrow Stem Cells are used to repair or replace damaged or diseased cells in the body.

Adult Bone Marrow Stem Cells are used to repair or replace damaged or diseased cells in the body. Used for Treatment of various conditions, including autoimmune diseases, blood disorders, and certain types of cancer.

At a glance

Mechanism of action

This is done by introducing healthy stem cells into the body, which can then differentiate into various cell types to replace damaged or diseased cells. The exact mechanism of action is complex and not fully understood, but it is thought to involve the differentiation of stem cells into various cell types, including immune cells, blood cells, and other cell types.

Approved indications

• Treatment of various conditions, including autoimmune diseases, blood disorders, and certain types of cancer

Common side effects

• Graft-versus-host disease

Key clinical trials

• Venetoclax or Placebo in Combination With Reduced-Intensity Conditioning Hematopoietic Cell (Bone Marrow/Blood Stem Cell) Transplant and as Maintenance Therapy After Transplant in Patients With Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) (PHASE2)
• Intensity-Modulated Radiation Therapy, Etoposide, and Cyclophosphamide Followed By Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia (PHASE1, PHASE2)
• A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies (PHASE2)
• Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia (PHASE2)
• Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS
• Pralatrexate With Bendamustine and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma (PHASE1, PHASE2)
• A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle (PHASE3)
• CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia (PHASE1)

Primary sources

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