Last reviewed 2026-04-23 · How we verify

ADT for 2 years

Androgen deprivation therapy (ADT) involves the use of medications to suppress the production of androgens, such as testosterone, which can fuel the growth of certain types of cancer.

Androgen deprivation therapy (ADT) involves the use of medications to suppress the production of androgens, such as testosterone, which can fuel the growth of certain types of cancer. Used for Prostate cancer, Metastatic prostate cancer.

At a glance

Mechanism of action

ADT works by targeting the androgen receptors in cancer cells, thereby inhibiting their growth and proliferation. This can be achieved through the use of medications that block the production of androgens or interfere with their action on cancer cells.

Approved indications

• Prostate cancer
• Metastatic prostate cancer

Common side effects

• Hot flashes
• Erectile dysfunction
• Fatigue
• Osteoporosis
• Anemia

Key clinical trials

• Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991) (PHASE3)
• Radiotherapy After Prostatectomy for Node Positive Prostate Cancer (PHASE3)
• A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC (PHASE3)
• Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer (PHASE3)
• Rezvilutamide for High-Risk Prostate Cancer After Surgery (NA)
• The University of Miami Adapt (UAdapt) Trial (PHASE2)
• Combination of Nivolumab Immunotherapy With Radiation Therapy and Androgen Deprivation Therapy (PHASE1, PHASE2)
• Therapeutic Effect of Cytoreductive Radical Prostatectomy in Men With Newly Diagnosed Metastatic Prostate Cancer (PHASE2)

Primary sources

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