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Administration of Propess
Propess is a vaginal insert that delivers dinoprostone (prostaglandin E2) directly to the cervix to promote cervical ripening and labor induction.
Propess is a vaginal insert that delivers dinoprostone (prostaglandin E2) directly to the cervix to promote cervical ripening and labor induction. Used for Cervical ripening and labor induction in pregnant women at or near term with medical or obstetric indication for labor induction.
At a glance
| Generic name | Administration of Propess |
|---|---|
| Sponsor | Tel-Aviv Sourasky Medical Center |
| Drug class | Prostaglandin E2 analog |
| Target | Prostaglandin E receptor (EP receptor) |
| Modality | Small molecule |
| Therapeutic area | Obstetrics |
| Phase | Phase 3 |
Mechanism of action
Propess contains dinoprostone, a naturally occurring prostaglandin E2 analog, which is released gradually from a polymer matrix insert placed in the vaginal fornix. The prostaglandin acts on cervical tissue to promote softening, effacement, and dilation of the cervix, facilitating the onset of labor. This localized delivery system provides sustained release over 12-24 hours, reducing systemic exposure compared to intravenous administration.
Approved indications
- Cervical ripening and labor induction in pregnant women at or near term with medical or obstetric indication for labor induction
Common side effects
- Uterine hyperstimulation with fetal heart rate changes
- Vaginal pain or irritation
- Fever
- Nausea
- Diarrhea
- Back pain
Key clinical trials
- PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM) (NA)
- Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter (PHASE4)
- Is There an Interest in Repeating the Vaginal Administration of Dinoprostone (Propess®), to Promote Induction of Labor of Pregnant Women at Term? (PHASE3)
- General Drug Use-results Survey on PROPESS Vaginal Inserts in Treatment for Initiation of Cervical Ripening in Patients at Term (From 37 Completed Weeks of Gestation)
- Dinoprostone Induction vs. Expectant Management After PROM at Term (PHASE4)
- Efficacy of Induction of Labor on Term Using a Double Balloon Catheter Compared to Dinoprostone Vaginal-insert (PHASE4)
- Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2 (PHASE2)
- Stepwise Labor Induction Following Failure of Prostaglandin Vaginal Insert for Labor Induction (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Administration of Propess CI brief — competitive landscape report
- Administration of Propess updates RSS · CI watch RSS
- Tel-Aviv Sourasky Medical Center portfolio CI