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Administration of Amoxicillin / clavulanic acid
Administration of Amoxicillin / clavulanic acid is a Beta-lactam antibiotic with beta-lactamase inhibitor Small molecule drug developed by Medical University of Vienna. It is currently in Phase 3 development for Bacterial infections caused by beta-lactamase-producing organisms (respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media).
Amoxicillin/clavulanic acid is a beta-lactam antibiotic combination that inhibits bacterial cell wall synthesis while clavulanic acid protects amoxicillin from beta-lactamase degradation.
Amoxicillin/clavulanic acid is a beta-lactam antibiotic combination that inhibits bacterial cell wall synthesis while clavulanic acid protects amoxicillin from beta-lactamase degradation. Used for Bacterial infections caused by beta-lactamase-producing organisms (respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media).
At a glance
| Generic name | Administration of Amoxicillin / clavulanic acid |
|---|---|
| Sponsor | Medical University of Vienna |
| Drug class | Beta-lactam antibiotic with beta-lactamase inhibitor |
| Target | Penicillin-binding proteins (PBPs); bacterial beta-lactamases |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Amoxicillin works by binding to penicillin-binding proteins and inhibiting cross-linking of peptidoglycan in the bacterial cell wall, leading to cell lysis and death. Clavulanic acid is a beta-lactamase inhibitor that irreversibly binds to bacterial beta-lactamases, preventing them from degrading amoxicillin and extending its spectrum of activity against beta-lactamase-producing organisms.
Approved indications
- Bacterial infections caused by beta-lactamase-producing organisms (respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media)
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Abdominal pain
- Allergic reactions
Key clinical trials
- APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis) (PHASE2)
- Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics (PHASE4)
- Efficacy of an Empirical Treatment With Amoxicillin-clavulanate (AC) Compared to the Combination Amoxicillin-clavulanate and Ciprofloxacin (AC+C) in the Outpatient Care of Chemotherapy-induced Fever in Adult Haematology Patients. (PHASE3)
- Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis (PHASE4)
- Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP (PHASE4)
- Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward (PHASE3)
- The MANTRA Trial (MANdibular TRauma and Antibiotic Use) (PHASE3)
- The Role of Microbiome in Recurrent Obesity Before and After Antibiotic/Placebo Treatment (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Administration of Amoxicillin / clavulanic acid CI brief — competitive landscape report
- Administration of Amoxicillin / clavulanic acid updates RSS · CI watch RSS
- Medical University of Vienna portfolio CI
Frequently asked questions about Administration of Amoxicillin / clavulanic acid
What is Administration of Amoxicillin / clavulanic acid?
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Who makes Administration of Amoxicillin / clavulanic acid?
What drug class is Administration of Amoxicillin / clavulanic acid in?
What development phase is Administration of Amoxicillin / clavulanic acid in?
What are the side effects of Administration of Amoxicillin / clavulanic acid?
What does Administration of Amoxicillin / clavulanic acid target?
Related
- Drug class: All Beta-lactam antibiotic with beta-lactamase inhibitor drugs
- Target: All drugs targeting Penicillin-binding proteins (PBPs); bacterial beta-lactamases
- Manufacturer: Medical University of Vienna — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Bacterial infections caused by beta-lactamase-producing organisms (respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media)
- Compare: Administration of Amoxicillin / clavulanic acid vs similar drugs
- Pricing: Administration of Amoxicillin / clavulanic acid cost, discount & access