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Administering propofol
Propofol is a rapid-acting intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system.
Propofol is a rapid-acting intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system. Used for Induction of general anesthesia, Maintenance of general anesthesia, Sedation for diagnostic and therapeutic procedures.
At a glance
| Generic name | Administering propofol |
|---|---|
| Sponsor | Iuliu Hatieganu University of Medicine and Pharmacy |
| Drug class | Intravenous sedative-hypnotic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol potentiates the effect of the inhibitory neurotransmitter GABA by binding to GABA-A receptors, leading to hyperpolarization of neuronal membranes and depression of central nervous system activity. This results in rapid onset of unconsciousness and sedation, making it suitable for induction and maintenance of general anesthesia as well as procedural sedation.
Approved indications
- Induction of general anesthesia
- Maintenance of general anesthesia
- Sedation for diagnostic and therapeutic procedures
- Sedation in intensive care unit patients
Common side effects
- Hypotension
- Apnea
- Airway obstruction
- Bradycardia
- Injection site pain
- Hypertension
- Tachycardia
Key clinical trials
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Actualities in Procedural Sedation: Remimazolam (PHASE4)
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Study Comparing Local/ MAC Anesthesia in Lumbar Decompression (EARLY_PHASE1)
- Treatment Response In ECT Patients
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation (PHASE4)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |