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Adjuvant letrozole (postmenopausal women) (adjuvant-letrozole-postmenopausal-women)
Adjuvant letrozole (postmenopausal women) (generic name: adjuvant-letrozole-postmenopausal-women) is a aromatase inhibitor drug developed by Pfizer. It is currently FDA-approved for Adjuvant treatment of hormone receptor-positive invasive breast cancer in postmenopausal women with disease recurrence or metastasis after 2-3 years of tamoxifen therapy.
Adjuvant letrozole is a marketed drug by Pfizer Inc. for postmenopausal women with hormone receptor-positive invasive breast cancer. It is used after 2-3 years of tamoxifen therapy. The mechanism of action is not specified in the provided information. Adjuvant letrozole is a key treatment option for this patient population. It has generated significant revenue of $21.2B. The drug has undergone 31 clinical trials.
At a glance
| Generic name | adjuvant-letrozole-postmenopausal-women |
|---|---|
| Sponsor | Pfizer |
| Drug class | aromatase inhibitor |
| Target | aromatase |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Approved indications
- Adjuvant treatment of hormone receptor-positive invasive breast cancer in postmenopausal women with disease recurrence or metastasis after 2-3 years of tamoxifen therapy
Common side effects
Drug interactions
- Warfarin
- Phenytoin
- Rifampicin
- Carbamazepine
- Phenobarbital
- St. John's Wort
- Tamoxifen
- Aromatase inhibitors (e.g., anastrozole, exemestane)
Key clinical trials
- Letrozole, Anastrozole, Exemestane, or Tamoxifen Citrate in Treating Postmenopausal Women With Breast Cancer (PHASE3)
- A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer (PHASE3)
- Phase IIIb Study of Ribociclib + ET in Early Breast Cancer (PHASE3)
- Neoadjuvant Letrozole in Postmenopausal Women With Hormone Receptor-Positive, HER2-Negative, Node Positive, Early-Stage Breast Cancer. (PHASE2)
- A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery (NA)
- PErsonalized TREatment of High-risk MAmmary Cancer - the PETREMAC Trial (PHASE2)
- Serum Estradiol Levels In Postmenopausal Women With Breast Cancer Receiving Adjuvant Aromatase Inhibitors and Vaginal Estrogen (NA)
- Impact of Omitting Chemo Based on Patient's Selection for ER-Positive, HER2-Negative Breast Cancer With Ribociclib and Endocrine Therapy (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Adjuvant letrozole (postmenopausal women) CI brief — competitive landscape report
- Adjuvant letrozole (postmenopausal women) updates RSS · CI watch RSS
- Pfizer portfolio CI
Frequently asked questions about Adjuvant letrozole (postmenopausal women)
What is Adjuvant letrozole (postmenopausal women)?
What is Adjuvant letrozole (postmenopausal women) used for?
Who makes Adjuvant letrozole (postmenopausal women)?
What is the generic name of Adjuvant letrozole (postmenopausal women)?
What drug class is Adjuvant letrozole (postmenopausal women) in?
What development phase is Adjuvant letrozole (postmenopausal women) in?
What does Adjuvant letrozole (postmenopausal women) target?
Related
- Drug class: All aromatase inhibitor drugs
- Target: All drugs targeting aromatase
- Manufacturer: Pfizer — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Adjuvant treatment of hormone receptor-positive invasive breast cancer in postmenopausal women with disease recurrence or metastasis after 2-3 years of tamoxifen therapy
- Compare: Adjuvant letrozole (postmenopausal women) vs similar drugs
- Pricing: Adjuvant letrozole (postmenopausal women) cost, discount & access