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Adapalene-BPO Gel
Adapalene-BPO is a combination topical gel that uses a retinoid (adapalene) to normalize skin cell turnover and reduce inflammation, combined with benzoyl peroxide to kill acne-causing bacteria and provide additional anti-inflammatory effects.
Adapalene-BPO is a combination topical gel that uses a retinoid (adapalene) to normalize skin cell turnover and reduce inflammation, combined with benzoyl peroxide to kill acne-causing bacteria and provide additional anti-inflammatory effects. Used for Acne vulgaris.
At a glance
| Generic name | Adapalene-BPO Gel |
|---|---|
| Sponsor | Galderma Brasil Ltda. |
| Drug class | Retinoid + peroxide combination |
| Target | Retinoic acid receptors (adapalene); bacterial cell membrane and proteins (benzoyl peroxide) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Adapalene is a third-generation retinoid that binds to retinoic acid receptors, promoting keratinocyte differentiation and reducing comedone formation. Benzoyl peroxide acts as an antimicrobial agent against Cutibacterium acnes (formerly Propionibacterium acnes) and generates reactive oxygen species that reduce bacterial colonization. Together, they address multiple pathogenic factors in acne: follicular hyperkeratinization, bacterial proliferation, and inflammation.
Approved indications
- Acne vulgaris
Common side effects
- Erythema
- Dryness
- Peeling
- Irritation
- Photosensitivity
Key clinical trials
- Experience With Topical Acne Treatment (EARLY_PHASE1)
- Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel (PHASE2)
- MC RCT - BPO vs Adapalene (PHASE3)
- Pirfenidone Plus M-DDO Gel in Moderate and Severe Acne (PHASE1, PHASE2)
- Adapalene 0.3% - Benzoyl Peroxide 2.5% Gel and Risk of Formation of Atrophic Acne Scars (PHASE4)
- Adapalene BPO Gel Pump, Moisturizer SPF 30 and Foam Wash in Patients With Mild to Moderate Acne Vulgaris (PHASE4)
- Assessment of Subjects' Efficacy and Experiences Using Adapalene BPO Gel in the Treatment of Acne Vulgaris (PHASE4)
- Adapalene-Benzoy Peroxide (BPO) Gel in the Treatment of Acne Vulgaris as a 6-month Maintenance (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Adapalene-BPO Gel CI brief — competitive landscape report
- Adapalene-BPO Gel updates RSS · CI watch RSS
- Galderma Brasil Ltda. portfolio CI