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Adapalene/Benzoyl Peroxide Gel 0.3-2.5%
Adapalene/Benzoyl Peroxide Gel 0.3-2.5% is a Retinoid + peroxide combination Small molecule drug developed by Derm Research, PLLC. It is currently FDA-approved for Acne vulgaris. Also known as: Epiduo Forte 0.3%-2.5% Topical Gel.
Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity.
Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity. Used for Acne vulgaris.
At a glance
| Generic name | Adapalene/Benzoyl Peroxide Gel 0.3-2.5% |
|---|---|
| Also known as | Epiduo Forte 0.3%-2.5% Topical Gel |
| Sponsor | Derm Research, PLLC |
| Drug class | Retinoid + peroxide combination |
| Target | Retinoic acid receptors (adapalene); bacterial cell membrane and proteins (benzoyl peroxide) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Adapalene binds to retinoic acid receptors to regulate gene expression, reducing comedone formation and normalizing follicular epithelial differentiation. Benzoyl peroxide acts as an oxidizing agent that generates reactive oxygen species, killing Cutibacterium acnes (formerly Propionibacterium acnes) and reducing bacterial resistance. Together, they provide complementary anti-inflammatory and antimicrobial effects for acne treatment.
Approved indications
- Acne vulgaris
Common side effects
- Erythema
- Scaling/peeling
- Dryness
- Irritation
- Photosensitivity
Key clinical trials
- Experience With Topical Acne Treatment (EARLY_PHASE1)
- Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel (PHASE2)
- A Treatment for Severe Inflammatory Acne Subjects (PHASE4)
- Adapalene 0.3% - Benzoyl Peroxide 2.5% Gel and Risk of Formation of Atrophic Acne Scars (PHASE4)
- Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients (PHASE4)
- Subject Reported Outcomes With Use of Adapalene 0.3% - Benzoyl Peroxide (BPO) 2.5% in Dark Skin Acne (PHASE3)
- Clinical End Point Study of Generic Adapalene and Benzoyl Peroxide Gel Versus Epiduo® Forte Gel in Treatment of Acne Vulgaris (PHASE3)
- The Use of Oracea and Epiduo Forte in Severe Acne Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Adapalene/Benzoyl Peroxide Gel 0.3-2.5% CI brief — competitive landscape report
- Adapalene/Benzoyl Peroxide Gel 0.3-2.5% updates RSS · CI watch RSS
- Derm Research, PLLC portfolio CI
Frequently asked questions about Adapalene/Benzoyl Peroxide Gel 0.3-2.5%
What is Adapalene/Benzoyl Peroxide Gel 0.3-2.5%?
How does Adapalene/Benzoyl Peroxide Gel 0.3-2.5% work?
What is Adapalene/Benzoyl Peroxide Gel 0.3-2.5% used for?
Who makes Adapalene/Benzoyl Peroxide Gel 0.3-2.5%?
Is Adapalene/Benzoyl Peroxide Gel 0.3-2.5% also known as anything else?
What drug class is Adapalene/Benzoyl Peroxide Gel 0.3-2.5% in?
What development phase is Adapalene/Benzoyl Peroxide Gel 0.3-2.5% in?
What are the side effects of Adapalene/Benzoyl Peroxide Gel 0.3-2.5%?
What does Adapalene/Benzoyl Peroxide Gel 0.3-2.5% target?
Related
- Drug class: All Retinoid + peroxide combination drugs
- Target: All drugs targeting Retinoic acid receptors (adapalene); bacterial cell membrane and proteins (benzoyl peroxide)
- Manufacturer: Derm Research, PLLC — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Acne vulgaris
- Also known as: Epiduo Forte 0.3%-2.5% Topical Gel
- Compare: Adapalene/Benzoyl Peroxide Gel 0.3-2.5% vs similar drugs
- Pricing: Adapalene/Benzoyl Peroxide Gel 0.3-2.5% cost, discount & access