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AD182
AD182 is a small molecule targeting the orexin receptor for the treatment of narcolepsy.
AD182 is a small molecule targeting the orexin receptor for the treatment of narcolepsy. Used for Narcolepsy.
At a glance
| Generic name | AD182 |
|---|---|
| Sponsor | Apnimed |
| Drug class | orexin receptor antagonist |
| Target | orexin receptor |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 2 |
Mechanism of action
AD182 works by selectively binding to the orexin receptor, which is involved in the regulation of sleep-wake cycles. This binding leads to a decrease in the activity of orexin, a neurotransmitter that promotes wakefulness, resulting in improved sleep quality and reduced excessive daytime sleepiness in patients with narcolepsy.
Approved indications
- Narcolepsy
Common side effects
- Headache
- Nausea
- Dizziness
Key clinical trials
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |