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Protamin
Protamin is a Small molecule drug developed by University of Ioannina. It is currently FDA-approved for Heparin overdose. Also known as: viscoelastic testing (Clot-Pro), ACT.
Protamin is a heparin inhibitor, classified as an INHIBITOR drug. It is used to treat various conditions including Low Cardiac Output, Cardiac Surgery, CAD, Valve Heart Disease, and Coagulation Disorder.
At a glance
| Generic name | Protamin |
|---|---|
| Also known as | viscoelastic testing (Clot-Pro), ACT |
| Sponsor | University of Ioannina |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | FDA-approved |
Approved indications
- Heparin overdose
Common side effects
- Hypoglycemia
- Headache
- Influenza-like symptoms
- Upper respiratory tract infection
- Dyspepsia
- Headache
- Diarrhea
- Neuropathy
- Back pain
- Diarrhea
- Pharyngitis
- Pharyngitis
Serious adverse events
- Severe Hypoglycemia
- Severe Hypoglycemia
- Anaphylaxis
- Worsening of diabetic retinopathy
- Acute painful peripheral neuropathy
- Lipodystrophy
- Pruritus
- Erythema
- Edema
- Ophthalmologic refraction disorder
Key clinical trials
- Heparin Based on Ideal Body Weight for Cardiopulmonary Bypass in Obese Patients (PHASE4)
- Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass. (NA)
- Adjusted Calculation of Heparin and Protamin Dosing and Correlation With Postoperative Bleeding and Transfusions (PHASE4)
- Peptide-specific Vaccination in HLA-A*02 Positive Patients With Biochemical Recurrence After Radical Prostatectomy (PHASE1, PHASE2)
- The Copenhagen Insulin and Metformin Therapy Trial (PHASE4)
- A Randomised, Single Centre, Double-Blind, Two-Period Crossover, Glucose Clamp Trial (PHASE1)
- Preop Hemodialysis or Intraop Ultrafiltration for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery (PHASE3)
- The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Protamin CI brief — competitive landscape report
- Protamin updates RSS · CI watch RSS
- University of Ioannina portfolio CI
Frequently asked questions about Protamin
What is Protamin?
What is Protamin used for?
Who makes Protamin?
Is Protamin also known as anything else?
What development phase is Protamin in?
What are the side effects of Protamin?
Related
- Manufacturer: University of Ioannina — full pipeline
- Therapeutic area: All drugs in Other
- Indication: Drugs for Heparin overdose
- Also known as: viscoelastic testing (Clot-Pro), ACT
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing