Last reviewed 2026-04-21 · How we verify

ACP

ACP is an autologous chondrocyte product that replaces damaged cartilage by implanting the patient's own cultured cartilage cells into the defect site.

ACP is an autologous chondrocyte product that replaces damaged cartilage by implanting the patient's own cultured cartilage cells into the defect site. Used for Symptomatic cartilage defects of the knee in adults.

At a glance

Mechanism of action

ACP (Autologous Chondrocyte Implantation) involves harvesting healthy cartilage cells from the patient, expanding them in culture, and surgically implanting them back into areas of cartilage damage. This regenerative approach aims to restore cartilage structure and function, reducing pain and improving joint mobility in patients with focal cartilage lesions.

Approved indications

• Focal cartilage defects of the knee
• Symptomatic articular cartilage lesions

Common side effects

• Graft failure or hypertrophy
• Joint effusion
• Pain or swelling at implant site
• Infection

Key clinical trials

• Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (PHASE2)
• Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics (NA)
• Developing a Communication Intervention for People With Memory Challenges and Their Care Partners (NA)
• Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage. (PHASE2)
• Improving Medical Decision Making for Older Patients With End Stage Renal Disease (NA)
• I Kua na'u Advance Care Planning for Native Hawaiian Elders (NA)
• Home Food Delivery for Diabetes Management in Patients of Rural Clinics (NA)
• Impact of Anterior Clinoid Process Pneumatization on Optic Canal and Retinal Nerve Fiber Layer

Primary sources

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