Last reviewed 2026-04-20 · How we verify

Aciphex

At a glance

Approved indications

• Duodenal Ulcer due to H. Pylori
• Duodenal ulcer disease
• Gastroesophageal reflux disease
• Maintenance of Healing Gastroesophageal Reflux
• Multiple endocrine adenomas
• Pathological Gastric Hypersecretory Condition
• Peptic ulcer
• Systemic mast cell disease
• Zollinger-Ellison syndrome

Common side effects

• Pain
• Pharyngitis
• Flatulence
• Infection
• Constipation
• Diarrhea
• Headache
• Nausea
• Vomiting
• Abdominal pain
• Taste perversion
• Dry mouth

Serious adverse events

• Hepatitis
• Hepatic encephalopathy
• Hepatic enzyme increase

Key clinical trials

• Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib (PHASE1)
• Effect of ZaStaprazan on Platelet Reactivity of Clopidogrel After PercuTaneous CoronAry InteRvention (PHASE4)
• A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy Participants (PHASE1)
• The Impact of Helicobacter Pylori Eradication on the Vaginal Microecology Change
• Yiwei Jiaohuang Ointment for Gastrointestinal Bleeding Associated With Oral Antithrombotic Agents (EARLY_PHASE1)
• Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy and Bismuth Quadruple Therapy (NA)
• Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy, Vonoprazan-amoxicillin Dual Therapy and Proton Pump Inhibitor-based Standard Triple Therapy for Hp Eradication (NA)
• Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.