Last reviewed 2026-04-20 · How we verify

Acetylcystein

At a glance

Approved indications

• Amyloidosis
• Atelectasis due to Mucous Obstruction
• Bronchiectasis
• Bronchitis
• Contrast Media-Induced Nephrotoxicity Prevention
• Cystic fibrosis of the lung
• General anesthesia
• Poisoning by acetaminophen
• Support of pincer nail correction
• Thick Bronchial Secretions

Common side effects

• Nausea
• Vomiting
• Stomatitis
• Fever
• Rhinorrhea
• Drowsiness
• Clamminess
• Chest tightness
• Irritation to tracheal and bronchial tracts

Serious adverse events

• Bronchoconstriction
• Bronchospasm
• Hemoptysis
• Acquired sensitization to acetylcysteine
• Dermal eruptions

Key clinical trials

• Plasma Exchange for Amanita Toxin-induced Acute Liver Failure
• Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients (PHASE2)
• NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major (PHASE1)
• RenalGuard System and Contrast Media (PHASE3)
• Hypertrophic Regression With N-Acetylcysteine in HCM (PHASE1)
• Clinical Trial of N-acetylcysteine Versus Placebo Efficacy in the Cannabis Withdrawal (PHASE2)
• Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic (NA)
• Use of Mucolytic Solution Before Upper Endoscopy (NA)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Acetylcystein CI brief — competitive landscape report
• Acetylcystein updates RSS · CI watch RSS
• University Hospital, Strasbourg, France portfolio CI