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acetaminophen, IV preparation
Acetaminophen inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever.
Acetaminophen inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever. Used for Acute pain management, Fever reduction, Post-operative pain.
At a glance
| Generic name | acetaminophen, IV preparation |
|---|---|
| Also known as | Ofirmev |
| Sponsor | The University of Texas Health Science Center at San Antonio |
| Drug class | Analgesic and antipyretic |
| Target | Cyclooxygenase (COX), primarily central nervous system isoforms |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Fever |
| Phase | FDA-approved |
Mechanism of action
Acetaminophen works primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing prostaglandin production and thereby lowering pain perception and body temperature set point. The IV formulation provides rapid systemic delivery for faster onset of analgesia and antipyresis compared to oral routes. The exact molecular mechanism remains incompletely understood but does not involve significant peripheral anti-inflammatory activity like NSAIDs.
Approved indications
- Acute pain management
- Fever reduction
- Post-operative pain
Common side effects
- Hepatotoxicity (at high doses or overdose)
- Infusion site reactions
- Nausea
- Vomiting
Key clinical trials
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma (PHASE2)
- Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy (NA)
- Post-Op Pain Control for Prophylactic Intramedullary Nailing. (PHASE3)
- Comparison of Ropivacaine-Poloxamer 407 Hydrogel and TAP Block for Postoperative Pain Management in Laparoscopic/Robotic Gastrectomy (NA)
- Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery (PHASE3)
- EOIB for Laparoscopic Cholecystectomy (NA)
- Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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