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Acetaminophen Injection
Acetaminophen inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever.
Acetaminophen inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever. Used for Acute pain management, Fever reduction.
At a glance
| Generic name | Acetaminophen Injection |
|---|---|
| Also known as | Tylenol, paracetamol, APAP Oral, Provase, Test ACM |
| Sponsor | Mount Sinai Hospital, Canada |
| Drug class | Analgesic and antipyretic |
| Target | Cyclooxygenase (COX) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Acetaminophen works primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing prostaglandin production. This leads to decreased pain perception and lowering of the hypothalamic set point for body temperature. The intravenous formulation provides rapid systemic delivery for acute pain and fever management in patients unable to take oral medication.
Approved indications
- Acute pain management
- Fever reduction
Common side effects
- Hepatotoxicity
- Nausea
- Vomiting
- Infusion site reactions
Key clinical trials
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- Daratumumab in STK11 Mutated NSCLC (PHASE2)
- The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
- A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |