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Acetaminophen & Indomethacin
This combination reduces pain and inflammation through dual inhibition of cyclooxygenase (COX) enzymes and direct analgesic action.
This combination reduces pain and inflammation through dual inhibition of cyclooxygenase (COX) enzymes and direct analgesic effects. Used for Pain management (specific indications not clearly defined in available literature).
At a glance
| Generic name | Acetaminophen & Indomethacin |
|---|---|
| Also known as | Tylenol, Indocin |
| Sponsor | Queen's University |
| Drug class | Analgesic/Anti-inflammatory combination |
| Target | COX-1, COX-2 (indomethacin); central nervous system analgesic pathways (acetaminophen) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Acetaminophen works primarily as a centrally-acting analgesic and antipyretic, while indomethacin is a non-selective COX inhibitor that reduces prostaglandin synthesis to decrease inflammation and pain. Together, they provide complementary analgesic and anti-inflammatory effects for pain management.
Approved indications
- Pain management (specific indications not clearly defined in available literature)
Common side effects
- Gastrointestinal upset
- Hepatotoxicity (acetaminophen)
- Renal impairment (indomethacin)
- Dizziness
Key clinical trials
- Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction (PHASE2, PHASE3)
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- E7 TCR T Cells for Human Papillomavirus-Associated Cancers (PHASE1, PHASE2)
- Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (PHASE2, PHASE3)
- Phase 2 Herniorrhaphy Study for Opioid Elimination (PHASE2)
- Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients (PHASE4)
- Optimizing Pain Treatment in Children On Mechanical Ventilation (PHASE3)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Acetaminophen & Indomethacin CI brief — competitive landscape report
- Acetaminophen & Indomethacin updates RSS · CI watch RSS
- Queen's University portfolio CI