Last reviewed · How we verify
Acetaminophen, Ibuprofen, Oxycodone
This combination analgesic works through three complementary pathways: acetaminophen and ibuprofen reduce pain and fever via different mechanisms, while oxycodone provides opioid-based pain relief for moderate to severe pain.
This combination analgesic works through three complementary pathways: acetaminophen and ibuprofen reduce pain and fever via different mechanisms, while oxycodone provides opioid-based pain relief for moderate to severe pain. Used for Moderate to severe acute pain.
At a glance
| Generic name | Acetaminophen, Ibuprofen, Oxycodone |
|---|---|
| Also known as | Tylenol (Acetaminophen) |
| Sponsor | University of Oklahoma |
| Drug class | Combination analgesic (acetaminophen + NSAID + opioid) |
| Target | Prostaglandin synthesis inhibition (acetaminophen), COX-1/COX-2 inhibition (ibuprofen), mu-opioid receptor (oxycodone) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Acetaminophen inhibits prostaglandin synthesis in the central nervous system, ibuprofen is a non-selective NSAID that blocks COX-1 and COX-2 enzymes to reduce inflammation and pain, and oxycodone is a mu-opioid receptor agonist that modulates pain perception in the central nervous system. This triple combination targets pain through multiple mechanisms for enhanced analgesic efficacy.
Approved indications
- Moderate to severe acute pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Drowsiness
- Gastrointestinal upset
- Respiratory depression
Key clinical trials
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Post-operative Pain Management in Children With Supracondylar Humerus Fractures (PHASE4)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery (PHASE4)
- SCHF Post-Op Study Between Opioid and Non-Opioid Pain Management (PHASE4)
- The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair (PHASE4)
- Reduced Opioid Prescription After Laparoscopic Hysterectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |