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Acetaminophen, Analgesics, Non-Narcotic
Acetaminophen, Analgesics, Non-Narcotic is a Non-narcotic analgesic and antipyretic Small molecule drug developed by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. It is currently in Phase 3 development for Mild to moderate pain, Fever reduction. Also known as: Tylenol.
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Used for Mild to moderate pain, Fever reduction.
At a glance
| Generic name | Acetaminophen, Analgesics, Non-Narcotic |
|---|---|
| Also known as | Tylenol |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Drug class | Non-narcotic analgesic and antipyretic |
| Target | Cyclooxygenase (COX), primarily central nervous system isoforms |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Acetaminophen is believed to work primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing the production of prostaglandins that mediate pain and fever signaling. Unlike NSAIDs, it has minimal peripheral anti-inflammatory effects and does not significantly inhibit COX in peripheral tissues, making it gentler on the gastrointestinal tract and cardiovascular system.
Approved indications
- Mild to moderate pain
- Fever reduction
Common side effects
- Hepatotoxicity (at high doses or chronic use)
- Nausea
- Rash
Key clinical trials
- Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction (PHASE2, PHASE3)
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Evaluating Suzetrigine for Pain Control Following TKA (PHASE3)
- Opioid-Sparing Joint Replacement (PHASE3)
- SCHF Post-Op Study Between Opioid and Non-Opioid Pain Management (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Acetaminophen, Analgesics, Non-Narcotic CI brief — competitive landscape report
- Acetaminophen, Analgesics, Non-Narcotic updates RSS · CI watch RSS
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's portfolio CI
Frequently asked questions about Acetaminophen, Analgesics, Non-Narcotic
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Related
- Drug class: All Non-narcotic analgesic and antipyretic drugs
- Target: All drugs targeting Cyclooxygenase (COX), primarily central nervous system isoforms
- Manufacturer: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Mild to moderate pain
- Indication: Drugs for Fever reduction
- Also known as: Tylenol
- Compare: Acetaminophen, Analgesics, Non-Narcotic vs similar drugs
- Pricing: Acetaminophen, Analgesics, Non-Narcotic cost, discount & access