Last reviewed 2026-04-20 · How we verify

Sectral (ACEBUTOLOL)

Sectral (acebutolol) is a beta-adrenergic blocker, a small molecule drug that targets the beta-1 adrenergic receptor. It was originally developed by Promius Pharma and is used to treat hypertensive disorders and ventricular premature beats. Sectral is off-patent, with multiple generic manufacturers available. It has a half-life of 3.5 hours and bioavailability of 37%. As a beta-blocker, Sectral is used to slow the heart rate and reduce blood pressure.

At a glance

Approved indications

• Hypertensive disorder
• Ventricular premature beats

Common side effects

• Chest Pain
• Edema
• Dizziness
• Fatigue
• Headache
• Depression
• Rash
• Constipation
• Diarrhea
• Dyspepsia
• Flatulence
• Nausea

Drug interactions

• acetohexamide
• chlorpropamide
• clonidine
• disopyramide
• epinephrine
• felodipine
• glibenclamide
• glipizide
• indomethacin
• piroxicam
• sulindac
• tolazamide

Key clinical trials

• N-of-1 for Beta-Blockers in Cardiac Amyloidosis (PHASE4)
• A Preliminary Study for INFORMED (PHASE4)
• Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF (PHASE4)
• Impact of Beta-blockers on Physical Function in HFpEF (PHASE4)
• ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
• Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial (NA)
• Kangaroo Mother Care to Prevent Hypothermia in Term Infants (NA)
• Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma (PHASE3)

Primary sources

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