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ACAM2000 Smallpox Vaccine
ACAM2000 Smallpox Vaccine works by stimulating an immune response to the smallpox virus.
ACAM2000 Smallpox Vaccine works by stimulating an immune response to the smallpox virus. Used for Prevention of smallpox.
At a glance
| Generic name | ACAM2000 Smallpox Vaccine |
|---|---|
| Also known as | ACAM2000® |
| Sponsor | Emergent BioSolutions |
| Modality | Biologic |
| Therapeutic area | Immunology |
| Phase | Phase 2 |
Mechanism of action
This is achieved through the introduction of a live, attenuated smallpox virus to the body, which triggers an immune response and provides immunity against smallpox. The vaccine is administered through multiple subcutaneous injections.
Approved indications
- Prevention of smallpox
Common side effects
- Pain, redness, swelling, or itching at the injection site
Key clinical trials
- Prospective Study for the FOLLOW-UP of Human Monkeypox Cases and Smallpox Vaccinees at Risk
- A Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of MVA-BN Yellow Fever Vaccine With and Without Montanide ISA-720 Adjuvant in 18-45 Year Old Healthy Volunteers (PHASE1)
- Evaluating the Human Immune Response to the JYNNEOS Vaccine (EARLY_PHASE1)
- MVA Post-Event: Administration Timing and Boost Study (PHASE1, PHASE2)
- Evaluation of Effectiveness and Safety of LC16m8 Mpox Vaccine in the Democratic Republic of Congo (DRC)
- Efficacy/Effectiveness, Safety, and Immunogenicity of LC16m8 Mpox Vaccine in Colombia (PHASE3)
- Pilot-RCT With Individualized Homeopathic Treatment in the Children With Autism Spectrum Disorder (PHASE4)
- Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ACAM2000 Smallpox Vaccine CI brief — competitive landscape report
- ACAM2000 Smallpox Vaccine updates RSS · CI watch RSS
- Emergent BioSolutions portfolio CI