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Arasine (ACADESINE)
Arasine works by increasing the levels of adenosine in the body, which helps to improve cardiac function and reduce ischemia.
Arasine (ACADESINE) is a small molecule drug in the acadesine class, originally developed by but currently owned by . It is used to treat , although its exact target is unknown. The commercial status of Arasine is unclear, as it is unknown whether it is patented or has generic manufacturers. Key safety considerations include its low bioavailability of 10%. Arasine's FDA approval status and off-patent status are also unknown.
At a glance
| Generic name | ACADESINE |
|---|---|
| Drug class | acadesine |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | discontinued |
Mechanism of action
Think of Arasine like a messenger that helps the heart work better. It increases the levels of adenosine, a natural substance that helps to relax blood vessels and improve blood flow to the heart. This can help to reduce the risk of heart damage during times of stress or low blood flow.
Approved indications
Common side effects
Key clinical trials
- GFM-Acadesine: A Phase I-II Trial of Acadesine (PHASE1,PHASE2)
- The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED) (PHASE3)
- Safety and Tolerability Open Label Dose Escalation Study of Acadesine in B-CLL Patients (PHASE1,PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |