Last reviewed 2026-04-23 · How we verify

A2

A2 is a medication that works by inhibiting the reuptake of norepinephrine, serotonin, and dopamine.

A2 is a medication that works by inhibiting the reuptake of norepinephrine, serotonin, and dopamine. Used for Major depressive disorder.

At a glance

Mechanism of action

This action increases the levels of these neurotransmitters in the brain, which can help improve mood and reduce symptoms of depression. A2 is a norepinephrine-dopamine reuptake inhibitor (NDRIs).

Approved indications

• Major depressive disorder

Common side effects

• Nausea
• Headache
• Dizziness
• Insomnia
• Fatigue

Key clinical trials

• A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001) (PHASE3)
• A Screening Program to Improve the Early Detection of Sporadic Pancreatic Cancer in Individuals With a High-Risk of Developing Pancreatic Cancer (NA)
• Dietary Intervention on Atopy (NA)
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial (PHASE2)
• A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus (PHASE2, PHASE3)
• Exploring the Efficacy of a Breathing Training Intervention in Patients With Emotionally Regulated Sleep Disorders (NA)
• Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE) (PHASE3)
• A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia (PHASE1)

Primary sources

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