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A (Chloraprep)
Chloraprep is an antimicrobial skin antiseptic that kills bacteria and other microorganisms on the skin surface through oxidative damage.
Chloraprep is an antimicrobial skin antiseptic that kills bacteria and other microorganisms on the skin surface through oxidative damage. Used for Skin antisepsis prior to surgery or invasive procedures, Skin preparation for central venous catheter insertion, General skin antisepsis and wound cleansing.
At a glance
| Generic name | A (Chloraprep) |
|---|---|
| Also known as | Chloraprep |
| Sponsor | Instituto de Investigacion Sanitaria La Fe |
| Drug class | Topical antiseptic |
| Target | Bacterial cell membrane and proteins |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention / Dermatology |
| Phase | FDA-approved |
Mechanism of action
Chloraprep combines chlorhexidine gluconate and isopropyl alcohol to provide rapid and sustained antimicrobial activity. Chlorhexidine disrupts bacterial cell membranes and denatures proteins, while isopropyl alcohol provides rapid bactericidal action. Together, these agents reduce skin flora to prevent surgical site infections and other skin-related infections.
Approved indications
- Skin antisepsis prior to surgery or invasive procedures
- Skin preparation for central venous catheter insertion
- General skin antisepsis and wound cleansing
Common side effects
- Skin irritation or erythema
- Contact dermatitis
- Allergic reaction (rare)
Key clinical trials
- Trigger Point Injections Versus Lidocaine Patch for Myofascial Pain in the Emergency Department (PHASE4)
- Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections (PHASE4)
- Test for Pre Operative Skin Preparations (PHASE3)
- Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics (PHASE3)
- Preoperative Skin Preparation Evaluation (PHASE3)
- A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs (PHASE4)
- SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty (PHASE4)
- Pre-operative Alcohol Skin Solutions in Fractured Extremities (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- A (Chloraprep) CI brief — competitive landscape report
- A (Chloraprep) updates RSS · CI watch RSS
- Instituto de Investigacion Sanitaria La Fe portfolio CI