Last reviewed 2026-04-23 · How we verify

4F-PCC

4F-PCC is a synthetic cannabinoid receptor agonist.

4F-PCC is a synthetic cannabinoid receptor agonist. Used for Treatment of pain.

At a glance

Mechanism of action

It acts on the CB1 receptor, which is involved in various physiological processes, including pain modulation and mood regulation.

Approved indications

• Treatment of pain

Common side effects

• Dizziness
• Nausea
• Headache

Key clinical trials

• Evaluation of 4-Factor PCC in DOAC-associated Intracranial Hemorrhage
• Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB) (PHASE3)
• A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery (PHASE3)
• Study of OCTAPLEX in Patients With Acute Major Bleeding on DOAC Therapy With Factor Xa Inhibitor (PHASE3)
• A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants (PHASE1)
• Andexanet Alfa and 4F-PCC Use in Patients Hospitalised With an Anticoagulant-related Major Bleed
• Study of Octaplex, a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex® P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk. (PHASE3)
• Evaluation of the Efficacy of Early Bunching of a FF-PCC in Patients With Severe Traumatic Hemorrhage (NA)

Primary sources

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