Transthyretin Familial Amyloid Polyneuropathy — Patent Landscape

Aggregated US Orange Book patent estate across every approved drug for transthyretin familial amyloid polyneuropathy. 13 active patents protecting 1 drugs from 1+ originators. First major cliff: 2027. Daily refresh.

1
Approved drugs
13
Active US patents
64/100
Avg vulnerability
$700M
Annual revenue covered

Originators in Transthyretin Familial Amyloid Polyneuropathy

Companies holding active patents on drugs approved for this indication. Click through to each company's full patent dashboard.

Alnylam Pharmaceuticals 13 patents

Cliff calendar — next 15 years

Patent expiries per year across all drugs treating transthyretin familial amyloid polyneuropathy. Each bar = one year. Y-axis scaled to peak year (8 patents).

1
27
8
29
2
30
1
32
1
35

Approved drugs ranked by patent estate

Drug Originator Active patents Avg vuln Revenue First cliff
Onpattro
PATISIRAN SODIUM
 Alnylam Pharmaceuticals 13 64 $700M 2027-10-03

Most attackable patents

Highest vulnerability scores in the indication — paragraph IV / IPR / design-around candidates.

Patent Drug Type Vuln Expiry
9364435 Onpattro method of use 75 2029-04-15
8822668 Onpattro method of use 75 2029-04-15
10240152 Onpattro method of use 68 2029-10-20
9234196 Onpattro method of use 68 2029-10-20
8741866 Onpattro method of use 68 2029-10-20
8802644 Onpattro method of use 68 2030-10-21
8158601 Onpattro method of use 68 2030-11-10
8168775 Onpattro method of use 62 2032-08-10
11079379 Onpattro method of use 62 2035-08-27
8642076 Onpattro formulation 55 2027-10-03

Strongest defences

Lowest vulnerability scores — pillars of the indication's IP fortress.

Patent Drug Type Vuln Expiry
11141378 Onpattro formulation 55 2029-04-15
8492359 Onpattro formulation 55 2029-04-15
8058069 Onpattro formulation 55 2029-04-15
8642076 Onpattro formulation 55 2027-10-03
11079379 Onpattro method of use 62 2035-08-27
8168775 Onpattro method of use 62 2032-08-10
8158601 Onpattro method of use 68 2030-11-10
8802644 Onpattro method of use 68 2030-10-21
9234196 Onpattro method of use 68 2029-10-20
10240152 Onpattro method of use 68 2029-10-20

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