Last reviewed · How we verify
Severe pain
Approved treatments
- Heroin
Heroin works by binding to opioid receptors in the brain, mimicking the action of natural pain-relieving chemicals. - Catapres-Tts-1 · Lavipharm
- Dilaudid-Hp · Fresenius Kabi
Hydromorphone binds primarily to mu-opioid receptors, producing analgesia without a ceiling effect. - Subutex · Indivior
Buprenorphine is a partial agonist at mu-opioid receptors and antagonist at kappa-opioid receptors. - Olinvyk · Trevena
Olinvyk works by binding to the mu-type opioid receptor in the brain, which helps to reduce the perception of pain. - OxyContin · Purdue Pharma
- Naltrexon · Institute of Liver and Biliary Sciences, India
- pethidine
- Clonidin · Medical University of Vienna
- Methadone Hydrochloride · Specgx Llc
Methadone is a synthetic opioid that acts as a mu-agonist, providing analgesia and aiding in opioid addiction management. - Moramide
Dextromoramide works by binding to opioid receptors in the brain, spinal cord, and other areas to produce analgesia and euphoria. - Subutex · Purdue Pharma Lp
Buprenorphine binds to mu-opioid receptors as a partial agonist and kappa-opioid receptors as an antagonist. - Pethidin · Ain Shams University
- Heroin · MetroHealth Medical Center
- MS Contin · Generic (multiple manufacturers)
The prototypical opioid agonist that binds mu-opioid receptors in the CNS, providing potent analgesia and serving as the reference standard for all opioids. - Advil · Generic (originally Boots Group)
Ibuprofen inhibits prostaglandin synthetase, reducing pain, fever, and inflammation. - Meperidine Hydrochloride Preservative Free · Pfizer
Meperidine Hydrochloride Preservative Free works by binding to opioid receptors in the brain, altering the perception of and response to pain. - Toradol
- Dilaudid-Hp · Fresenius Kabi
Full mu-opioid receptor agonist providing analgesia through CNS opioid receptor activation. - Duramorph Pf · Pfizer
Duramorph Pf works by binding to opioid receptors in the brain and spinal cord, mimicking the natural pain-relieving chemicals in the body. - Opana Er · Endo
- OXYCONTIN® · Mundipharma (China) Pharmaceutical Co. Ltd
OxyContin is a medication that works by binding to opioid receptors in the brain, altering the way the body perceives pain. - Methadon · University of Utah
Clinical guidelines
- FDA label — any
Meperidine Hydrochloride Tablets and Oral Solution are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
Competitive intelligence
For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:
- Severe pain patent landscape — cliff calendar, originator estates, attackable patents
- Severe pain treatment landscape brief
- Severe pain treatment updates RSS
Frequently asked questions about Severe pain
What drugs treat Severe pain?
Tracked treatments include Heroin, Catapres-Tts-1, Dilaudid-Hp, Subutex, Olinvyk, OxyContin, Naltrexon, pethidine.
What is the treatment for Severe pain?
Standard treatment for Severe pain includes Heroin, Catapres-Tts-1, Dilaudid-Hp, Subutex, Olinvyk. See the treatment landscape page for first-line, second-line and salvage options.
What are the treatment guidelines for Severe pain?
FDA label publishes guidelines for Severe pain. 1 guideline references tracked.
Related
- Treatment landscape: Severe pain patent cliff · Severe pain CI report
- Treatment: Heroin
- Treatment: Catapres-Tts-1 · Lavipharm
- Treatment: Dilaudid-Hp · Fresenius Kabi
- Treatment: Subutex · Indivior
- Treatment: Olinvyk · Trevena
- All diseases: Browse the disease index · Disease landscape hub
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing