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Peripheral T-cell lymphoma
Approved treatments
- Immucillin H · Mundi Pharma
- Folotyn · Acrotech Biopharma Inc.
- Poteligeo · Kyowa Kirin
Poteligeo works by binding to the C-C chemokine receptor type 4, which is involved in the migration and proliferation of T-cells. - Istodax · Celgene
- Poteligeo · Kyowa Kirin Pharmaceutical Development Ltd
- Istodax · Teva Pharms Usa Inc
Romidepsin inhibits HDACs, leading to increased acetylation of histones and non-histone proteins, causing cell cycle arrest and apoptosis in cancer cells. - Chidamide · Sun Yat-sen University
- Beleodaq · Acrotech Biopharma
Beleodaq works by blocking the enzyme that removes acetyl groups from histones, altering gene expression. - Mogamulizumab-Kpkc · H. Lee Moffitt Cancer Center and Research Institute
12.1 Mechanism of Action Mogamulizumab-kpkc is a defucosylated, humanized IgG1 kappa monoclonal antibody that binds to CCR4, a G protein-coupled receptor for CC chemokines that is involved in the trafficking of lymphocytes to various organs. Non-clinical in vitro studies demonstrate mogamulizumab-kpkc binding targets a cell for antibody-dependent cellular cytotoxicity (ADCC) resulting in depletion of the target cells. CCR4 is expressed on the surface of some T-cell malignancies and is expressed on regulatory T-cells (Treg) and a subset of Th2 T-cells.
Competitive intelligence
For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:
- Peripheral T-cell lymphoma patent landscape — cliff calendar, originator estates, attackable patents
- Peripheral T-cell lymphoma treatment landscape brief
- Peripheral T-cell lymphoma treatment updates RSS
Frequently asked questions about Peripheral T-cell lymphoma
What drugs treat Peripheral T-cell lymphoma?
Tracked treatments include Immucillin H, Folotyn, Poteligeo, Istodax, Chidamide, Beleodaq, Mogamulizumab-Kpkc.
What is the treatment for Peripheral T-cell lymphoma?
Standard treatment for Peripheral T-cell lymphoma includes Immucillin H, Folotyn, Poteligeo, Istodax, Chidamide. See the treatment landscape page for first-line, second-line and salvage options.
Related
- Treatment landscape: Peripheral T-cell lymphoma patent cliff · Peripheral T-cell lymphoma CI report
- Treatment: Immucillin H · Mundi Pharma
- Treatment: Folotyn · Acrotech Biopharma Inc.
- Treatment: Poteligeo · Kyowa Kirin
- Treatment: Istodax · Celgene
- Treatment: Poteligeo · Kyowa Kirin Pharmaceutical Development Ltd
- All diseases: Browse the disease index · Disease landscape hub
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing