Last reviewed · How we verify
Lennox-Gastaut syndrome
Approved treatments
- Epidiolex · Jazz Pharms Res
Epidiolex works by inhibiting the activity of caspase-1, a protein involved in the inflammatory response and neuronal excitability. - Topamax · Janssen
- Phenytoin Sodium · Viatris
Phenytoin Sodium works by stabilizing the threshold against hyperexcitability caused by excessive stimulation. - Onfi · Lundbeck Pharms Llc
Onfi works by enhancing the activity of the neurotransmitter GABA, which helps calm excessive electrical activity in the brain. - Tegretol · Novartis AG (originally Geigy)
Carbamazepine reduces polysynaptic responses and blocks post-tetanic potentiation, potentially alleviating seizures and pain. - Ativan · Generic (originally Wyeth/Pfizer)
- Lamictal · GSK
- Banzel · Eisai
Banzel works by stabilizing inactivated sodium channels in the brain, reducing the frequency of seizures. - Klonopin · Generic (originally Roche)
- Carbamazepin · Enanta Pharmaceuticals, Inc
- phenobarbitone · Institute of Child Health
- Mysoline · Bausch Health
- Felbatol · Mylan Speciality Lp
Felbamate's exact mechanism is unknown, but it shows anticonvulsant activity in various animal models and interacts with the NMDA receptor-ionophore complex. - Dilantin · Pfizer
Phenytoin exerts its therapeutic effect by voltage-dependent blockade of membrane sodium channels. - Rufinamid · University of Zurich
- Topamax · Ataturk University
- Epidiolex · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Klonopin · Par Pharmaceutical, Inc.
Competitive intelligence
For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:
- Lennox-Gastaut syndrome patent landscape — cliff calendar, originator estates, attackable patents
- Lennox-Gastaut syndrome treatment landscape brief
- Lennox-Gastaut syndrome treatment updates RSS
Frequently asked questions about Lennox-Gastaut syndrome
What drugs treat Lennox-Gastaut syndrome?
Tracked treatments include Epidiolex, Topamax, Phenytoin Sodium, Onfi, Tegretol, Ativan, Lamictal, Banzel.
What is the treatment for Lennox-Gastaut syndrome?
Standard treatment for Lennox-Gastaut syndrome includes Epidiolex, Topamax, Phenytoin Sodium, Onfi, Tegretol. See the treatment landscape page for first-line, second-line and salvage options.
Related
- Treatment landscape: Lennox-Gastaut syndrome patent cliff · Lennox-Gastaut syndrome CI report
- Treatment: Epidiolex · Jazz Pharms Res
- Treatment: Topamax · Janssen
- Treatment: Phenytoin Sodium · Viatris
- Treatment: Onfi · Lundbeck Pharms Llc
- Treatment: Tegretol · Novartis AG (originally Geigy)
- All diseases: Browse the disease index · Disease landscape hub
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing