Fluid Retention In Heart Failure — Patent Landscape

Aggregated US Orange Book patent estate across every approved drug for fluid retention in heart failure. 16 active patents protecting 1 drugs from 1+ originators. First major cliff: 2026. Daily refresh.

1
Approved drugs
16
Active US patents
36/100
Avg vulnerability
$1.2B
Annual revenue covered

Originators in Fluid Retention In Heart Failure

Companies holding active patents on drugs approved for this indication. Click through to each company's full patent dashboard.

Otsuka 16 patents

Cliff calendar — next 15 years

Patent expiries per year across all drugs treating fluid retention in heart failure. Each bar = one year. Y-axis scaled to peak year (8 patents).

8
26
8
30

Approved drugs ranked by patent estate

Drug Originator Active patents Avg vuln Revenue First cliff
Samsca
TOLVAPTAN
Otsuka 16 36 $1.2B 2026-09-01

Most attackable patents

Highest vulnerability scores in the indication — paragraph IV / IPR / design-around candidates.

Patent Drug Type Vuln Expiry
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07
8501730 Samsca composition of matter 27 2026-09-01
8501730 Samsca composition of matter 27 2026-09-01

Strongest defences

Lowest vulnerability scores — pillars of the indication's IP fortress.

Patent Drug Type Vuln Expiry
8501730 Samsca composition of matter 22 2026-09-01
8501730 Samsca composition of matter 22 2026-09-01
8501730 Samsca composition of matter 22 2026-09-01
8501730 Samsca composition of matter 22 2026-09-01
8501730 Samsca composition of matter 22 2026-09-01
8501730 Samsca composition of matter 27 2026-09-01
8501730 Samsca composition of matter 27 2026-09-01
8501730 Samsca composition of matter 27 2026-09-01
10905694 Samsca formulation 48 2030-04-07
10905694 Samsca formulation 48 2030-04-07

Related