Chronic Graft Versus Host Disease — Patent Landscape

Aggregated US Orange Book patent estate across every approved drug for chronic graft versus host disease. 448 active patents protecting 1 drugs from 1+ originators. First major cliff: 2026. Daily refresh.

1
Approved drugs
448
Active US patents
43/100
Avg vulnerability
$3.2B
Annual revenue covered

Originators in Chronic Graft Versus Host Disease

Companies holding active patents on drugs approved for this indication. Click through to each company's full patent dashboard.

AbbVie 448 patents

Cliff calendar — next 15 years

Patent expiries per year across all drugs treating chronic graft versus host disease. Each bar = one year. Y-axis scaled to peak year (117 patents).

70
26
87
27
7
28
117
31
81
33
30
34
19
35
36
36
1
39

Approved drugs ranked by patent estate

Drug Originator Active patents Avg vuln Revenue First cliff
Imbruvica
ibrutinib
 AbbVie 448 43 $3.2B 2026-12-28

Most attackable patents

Highest vulnerability scores in the indication — paragraph IV / IPR / design-around candidates.

Patent Drug Type Vuln Expiry
8703780 Imbruvica method of use 76 2026-12-28
8952015 Imbruvica method of use 76 2026-12-28
8476284 Imbruvica method of use 76 2026-12-28
8563563 Imbruvica method of use 76 2027-04-26
8497277 Imbruvica method of use 71 2026-12-28
8476284 Imbruvica method of use 68 2026-12-28
8497277 Imbruvica method of use 68 2026-12-28
8703780 Imbruvica method of use 68 2026-12-28
8999999 Imbruvica method of use 64 2031-06-03
9801883 Imbruvica method of use 64 2031-06-03

Strongest defences

Lowest vulnerability scores — pillars of the indication's IP fortress.

Patent Drug Type Vuln Expiry
9296753 Imbruvica composition of matter 0 2033-10-30
9296753 Imbruvica composition of matter 0 2033-10-30
9296753 Imbruvica composition of matter 0 2033-10-30
9296753 Imbruvica composition of matter 0 2033-10-30
9296753 Imbruvica composition of matter 0 2033-10-30
9296753 Imbruvica composition of matter 0 2033-10-30
9296753 Imbruvica composition of matter 0 2033-10-30
10125140 Imbruvica composition of matter 0 2033-06-03
10106548 Imbruvica composition of matter 0 2033-06-03
10106548 Imbruvica composition of matter 0 2033-06-03

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