Crestor® vs Lipitor
Side-by-side comparison of Crestor® and Lipitor — mechanism, indications, safety, trials, sponsor, and pricing.
At a glance
| Crestor® | Lipitor |
|---|
| Generic name | Crestor® | Atorvastatin Calcium |
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| Sponsor | Pin Siang Medical Biotechnology Co., Ltd. | Pfizer |
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| Drug class | — | atorvastatin |
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| Molecular target | — | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Modality | Small molecule | Small molecule |
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| Phase | FDA-approved | FDA-approved |
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| Therapeutic area | — | Metabolic |
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| First approval | — | 1996 |
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Mechanism of action
| Crestor® | — |
|---|
| Lipitor | Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, a key enzyme in cholesterol synthesis. |
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Approved indications
Lipitor
- Angina pectoris
- Arteriosclerotic vascular disease
- Cerebrovascular accident
- Familial hypercholesterolemia - heterozygous
- Familial hypercholesterolemia - homozygous
- Familial type 3 hyperlipoproteinemia
- Hypercholesterolemia
- Hypertriglyceridemia
Common side effects
Lipitor
- Myopathy and Rhabdomyolysis
- Immune-Mediated Necrotizing Myopathy
- Hepatic Dysfunction
- Increases in HbA1c and Fasting Serum Glucose Levels
- Nasopharyngitis
- Arthralgia
- Diarrhea
- Pain in extremity
Further reading