cabotegravir, CAB · Infectious Disease Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA.
Cabotegravir Injectable Suspension · Infectious Disease Cabotegravir is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA.
Cabotegravir OLI · Infectious Disease / Virology Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human host cell DNA.
CAR · Infectious Disease / Virology CAR is a combination antiretroviral therapy containing cabotegravir and rilpivirine that suppresses HIV replication by inhibiting integrase and reverse transcriptase.
Dolutegravir (DTG) · Infectious Disease Dolutegravir inhibits HIV integrase, preventing the virus from inserting its genetic material into the host cell's DNA.
Etravirine (ETR) · Infectious Disease Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to HIV-1 reverse transcriptase and blocks its ability to convert viral RNA into DNA.
Fosamprenavir/ritonavir · Infectious Disease Fosamprenavir is a protease inhibitor that blocks HIV protease, preventing viral replication, while ritonavir acts as a pharmacokinetic booster to increase fosamprenavir levels.
FTC/TAF · Infectious Disease FTC/TAF is a fixed-dose combination of two nucleoside reverse transcriptase inhibitors that blocks HIV reverse transcriptase to prevent viral replication.
GI265235 · Infectious Disease GI265235 is an HIV integrase strand transfer inhibitor that prevents HIV from integrating its genetic material into host cell DNA.
HIV therapy · Infectious Disease / Virology ViiV Healthcare's HIV therapies work by inhibiting viral replication through various mechanisms including reverse transcriptase inhibition, protease inhibition, integrase inhibition, or entry inhibition, depending on the specific agent.
JULUCA · Infectious Disease / Virology JULUCA is a two-drug combination that inhibits HIV integrase and reverse transcriptase to suppress viral replication.
Lenacapavir long-acting · Infectious Disease Lenacapavir is a first-in-class HIV capsid inhibitor that binds to the HIV capsid protein and blocks the uncoating of viral RNA, preventing early steps of HIV replication.
Reyataz + Epzicom · Infectious Disease / Virology This combination inhibits HIV reverse transcriptase and protease to block viral replication.
Reyataz + Norvir + Truvada · Infectious Disease / Virology This combination inhibits HIV protease and reverse transcriptase to suppress viral replication and reduce HIV RNA levels.
Telzir® · Infectious Disease Telzir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
Tenofovir alafenamide/emtricitabine · Infectious Disease Tenofovir alafenamide and emtricitabine are nucleotide/nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
ZIAGEN® · Infectious Disease / Virology ZIAGEN (abacavir) is a nucleoside reverse transcriptase inhibitor that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
Phase 3 pipeline
ABC/DTG/3TC FDC · Infectious Disease / Virology A fixed-dose combination of three antiretroviral agents that inhibits HIV reverse transcriptase and integrase to suppress viral replication.
ABC/DTG/3TC immediate release tablets · Infectious Disease / Virology A fixed-dose combination of three antiretroviral agents that inhibit HIV reverse transcriptase and integrase to suppress viral replication.
ABC/DTG/3TC STR - Tablet · Infectious Disease / Virology A fixed-dose combination of three antiretroviral agents that inhibit HIV reverse transcriptase and integrase to suppress viral replication.
BIKTARVY Tablets (BIK) · Infectious Disease / Virology BIKTARVY is a fixed-dose combination of three antiretroviral agents that inhibit HIV replication through complementary mechanisms: reverse transcriptase inhibition, integrase inhibition, and protease inhibition.
BMS-663068 · Infectious Disease / Virology BMS-663068 is an HIV attachment inhibitor that blocks the interaction between HIV and the CD4 receptor on host cells, preventing viral entry.
CAB LA + RPV LA · Infectious Disease / Virology CAB LA and RPV LA are long-acting injectable antiretroviral agents that inhibit HIV reverse transcriptase and integrase to suppress viral replication.
CAB OLI · Infectious Disease / Virology CAB OLI is a long-acting injectable combination of cabotegravir and bictegravir that inhibits HIV integrase and reverse transcriptase to suppress viral replication.
Cabotegravir Tablets · Infectious Disease / Virology Cabotegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA.
Dolutegravir/abacavir/lamivudine FDC · Infectious Disease / Virology This fixed-dose combination inhibits HIV integrase and reverse transcriptase to prevent viral replication and reduce viral load in HIV-infected patients.
Dolutegravir film-coated dispersible tablets · Infectious Disease Dolutegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA.
Dolutegravir film-coated tablets · Infectious Disease Dolutegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA.
Dolutegravir + Lamivudine FDC · Infectious Disease / Virology Dolutegravir inhibits HIV integrase to prevent viral DNA integration into the host genome, while lamivudine inhibits reverse transcriptase to block viral replication.
Dolutegravir placebo twice daily · Infectious Disease / Virology This is a placebo control arm in a clinical trial; it contains no active drug and serves as a comparator to assess the efficacy of dolutegravir.
DTG · Infectious Disease DTG (dolutegravir) is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into human DNA.
DTG + 3TC FDC · Infectious Disease / Virology DTG (dolutegravir) inhibits HIV integrase to prevent viral replication, while 3TC (lamivudine) inhibits reverse transcriptase to block HIV from converting its RNA genome into DNA.
Efavirenz + Zidovudine/Lamivudine · Infectious Disease / Virology This combination uses a non-nucleoside reverse transcriptase inhibitor (efavirenz) plus two nucleoside reverse transcriptase inhibitors (zidovudine and lamivudine) to block HIV replication at multiple steps.
fosamprenavir (GW433908) · Infectious disease Fosamprenavir is a prodrug that is metabolized into amprenavir, a protease inhibitor.
GSK1349572 (dolutegravir) · Infectious Disease Dolutegravir inhibits HIV integrase, preventing the virus from inserting its genetic material into human DNA.
Lamivudine (3TC) · Infectious Disease / Virology Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV reverse transcriptase, preventing viral RNA from being converted into DNA and integrated into host cells.
LEXIVA (GW433908) · Infectious Disease Lexiva is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
LPV/RTV · Infectious Disease LPV/RTV is a combination of two protease inhibitors that block HIV protease, preventing the maturation of HIV virions and reducing viral replication.
Maraviroc + Zidovudine/Lamivudine · Infectious Disease / Virology This combination blocks HIV entry into CD4+ T cells via CCR5 antagonism while simultaneously inhibiting reverse transcriptase to suppress viral replication.
Ongoing cART regimen · Infectious Diseases cART regimens combine multiple antiretroviral drugs to suppress HIV replication by targeting different stages of the viral life cycle.
Oral CAB · Infectious Disease / Virology Oral CAB is a capsid assembly modulator that inhibits HIV capsid formation, preventing viral replication by disrupting the structural integrity of newly formed HIV particles.
Rilpivirine Injectable Suspension · Infectious Disease / Virology Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
Rilpivirine (RPV) LA · Infectious Diseases Rilpivirine (RPV) LA is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by blocking the replication of HIV-1.
Rilpivirine Tablets · Infectious Disease Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by blocking the replication of the HIV virus.
RPV LA · Infectious Disease RPV LA is a long-acting integrase inhibitor used to treat HIV-1 infection.
RPV OLI · Infectious Disease RPV OLI is a HIV integrase strand transfer inhibitor.
TAF based regimen (TBR) · Infectious Disease / Virology TAF (tenofovir alafenamide) is a nucleotide reverse transcriptase inhibitor that blocks HIV reverse transcriptase to prevent viral replication.
Tenofovir/emtricitabine FDC · Infectious Disease / Virology Tenofovir and emtricitabine are nucleotide/nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
Two NRTIs · Infectious Disease / Virology Two nucleoside reverse transcriptase inhibitors (NRTIs) work together to block HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and integrating into host cells.
Phase 2 pipeline
CAB Oral Tablets · Infectious Disease / Virology CAB (cabotegravir) is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into host cell DNA.
DTG based ARV regimen without ABC · Infectious Disease / Virology DTG (dolutegravir) is an integrase strand transfer inhibitor that blocks HIV integrase, preventing the virus from inserting its genetic material into host cell DNA.