L-asparaginase · Oncology L-asparaginase depletes asparagine in the bloodstream, starving asparagine-dependent leukemic cells of an essential amino acid required for protein synthesis.
Phase 3 pipeline
Gemcitabine plus Abraxane · Oncology Gemcitabine is a nucleoside analog that inhibits DNA synthesis, while Abraxane (paclitaxel albumin-bound) stabilizes microtubules to prevent cell division, together providing synergistic cytotoxic effects against cancer cells.
Irinotecan plus 5-FU plus leucovorin · Oncology This combination of irinotecan (a topoisomerase I inhibitor), 5-fluorouracil (a nucleotide analog), and leucovorin (a folate cofactor) works together to inhibit DNA synthesis and repair in cancer cells.
Phase 2 pipeline
ERY001 · Oncology ERY001 encapsulates chemotherapeutic agents within red blood cells to enhance their delivery to tumors while reducing systemic toxicity.