Abciximab; reteplase; abciximab placebo; abciximab · Cardiovascular Abciximab is a chimeric monoclonal antibody that blocks the glycoprotein IIb/IIIa receptor on platelet surfaces, preventing platelet aggregation and thrombus formation.
Methotrexate capsules · Oncology; Immunology Methotrexate inhibits dihydrofolate reductase, blocking the synthesis of purines and pyrimidines required for DNA replication and cell division.
Placebo; golimumab · Immunology Golimumab is a monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling.
Placebo (IP) Placebo produces no pharmacological effect and serves as an inert control in clinical trials.
Phase 2 pipeline
CNTO 1275 · Immunology CNTO 1275 is a fully human monoclonal antibody that targets the CD28 receptor.
CNTO 136 · Immunology CNTO 136 is a monoclonal antibody that targets interleukin-12 (IL-12) and interleukin-23 (IL-23), which are involved in inflammatory responses.
Infliximab; Gemcitabine · Immunology Infliximab is a chimeric monoclonal antibody that binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors.