Experimental drug: Olanzapine · Psychiatry/Neurology Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain.
Experimental drug: Ondansetron · Oncology, Gastroenterology, Anesthesia Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
Standard: Aprepitant · Oncology Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist.
Standard: Dexamethasone · Oncology, Rheumatology, Neurology Dexamethasone is a synthetic corticosteroid that functions as a potent anti-inflammatory agent by inhibiting the production of pro-inflammatory cytokines and mediators.
Standard: Ondansetron · Oncology Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting.