What are Soluble guanylate cyclase stimulator drugs?

Soluble guanylate cyclase stimulator drugs are pharmacologic agents that share a common mechanism (typically targeting Soluble guanylate cyclase (sGC)). 4 are currently marketed, with 2 more in clinical development.

What are the marketed Soluble guanylate cyclase stimulator drugs?

Marketed Soluble guanylate cyclase stimulator drugs include Riociguat (Adempas), Riociguat Oral Product, Verquvo, Adempas.

Soluble guanylate cyclase stimulator

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

4 marketed 2 in Phase 3

This page covers all Soluble guanylate cyclase stimulator drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Soluble guanylate cyclase (sGC), Guanylate cyclase soluble subunit beta-1.

Targets

Soluble guanylate cyclase (sGC) · Guanylate cyclase soluble subunit beta-1

Marketed (4)

Riociguat (Adempas) · Chinese University of Hong Kong · Cardiovascular
Riociguat is a soluble guanylate cyclase stimulator that directly activates the enzyme to increase cyclic GMP levels, promoting vasodilation and reducing pulmonary vascular resistance.
Riociguat Oral Product · University of Calgary · Cardiovascular
Riociguat is a soluble guanylate cyclase stimulator that increases cyclic GMP levels to promote vasodilation and reduce pulmonary vascular resistance.
Verquvo · Merck & Co. · Cardiovascular
Verquvo works by stimulating the enzyme guanylate cyclase to increase levels of a molecule called cGMP, which helps to relax blood vessels and improve heart function.
Adempas · Bayer · Metabolic
Adempas works by stimulating the soluble guanylate cyclase enzyme to increase levels of cyclic guanosine monophosphate (cGMP), a signaling molecule that helps to relax blood vessels.

Phase 3 pipeline (2)

Riociguat Pill · University of Arizona · Cardiovascular
Riociguat is a soluble guanylate cyclase stimulator that increases cyclic GMP levels to promote vasodilation and reduce pulmonary vascular resistance.
SOC: Soluble guanylate cyclase stimulator · Actelion · Cardiovascular
Soluble guanylate cyclase stimulators directly activate the enzyme soluble guanylate cyclase to increase intracellular cyclic GMP levels, promoting vasodilation and reducing pulmonary vascular resistance.

Patent intelligence

soluble guanylate cyclase stimulator patent landscape — aggregated cliff calendar, attackable patents, originator estates