What are ROCK inhibitor drugs?

ROCK inhibitor drugs are pharmacologic agents that share a common mechanism (typically targeting ROCK (Rho-associated coiled-coil-containing protein kinase)). 0 are currently marketed, with 3 more in clinical development.

ROCK inhibitor

0 marketed 2 in Phase 3 1 in Phase 2

This page covers all ROCK inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting ROCK (Rho-associated coiled-coil-containing protein kinase), ROCK.

Targets

ROCK (Rho-associated coiled-coil-containing protein kinase) · ROCK

Phase 3 pipeline (2)

DE-108 · Santen Pharmaceutical Co., Ltd. · Ophthalmology
DE-108 is a small molecule that inhibits Rho-associated protein kinase (ROCK) to reduce intraocular pressure by decreasing aqueous humor outflow resistance.
SHR8028 eye drops · Jiangsu HengRui Medicine Co., Ltd. · Ophthalmology
SHR8028 is a selective rho-associated protein kinase (ROCK) inhibitor administered as eye drops to reduce intraocular pressure in glaucoma.

Phase 2 pipeline (1)

ADX-2191 · Aldeyra Therapeutics, Inc. · Ophthalmology
ADX-2191 is designed to inhibit the activity of Rho-associated protein kinase (ROCK), which is involved in various cellular processes including inflammation and cell proliferation.