Quinoline antimalarial

This page covers all Quinoline antimalarial drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Plasmodium heme detoxification pathway; DNA/RNA synthesis, Heme; Toll-like receptors (immunomodulatory effects).

Targets

Plasmodium heme detoxification pathway; DNA/RNA synthesis · Heme; Toll-like receptors (immunomodulatory effects)

Marketed (2)

• Chloroquine profilaxis · Institut de Recherche pour le Developpement · Infectious Disease
  Chloroquine inhibits parasite growth by accumulating in parasite food vacuoles and interfering with heme detoxification and nucleic acid synthesis.
• Chloroquine (CQ) · London School of Hygiene and Tropical Medicine · Infectious Disease; Rheumatology
  Chloroquine is a quinoline antimalarial that accumulates in parasitic food vacuoles and inhibits heme polymerization, causing toxic heme accumulation and parasite death.