Purine analog immunosuppressant

This page covers all Purine analog immunosuppressant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Inosine monophosphate dehydrogenase (IMPDH), purine synthesis pathway, Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), inosine monophosphate dehydrogenase (IMPDH), Inosine monophosphate dehydrogenase (IMPDH), hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

Targets

Inosine monophosphate dehydrogenase (IMPDH), purine synthesis pathway · Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), inosine monophosphate dehydrogenase (IMPDH) · Inosine monophosphate dehydrogenase (IMPDH), hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

Marketed (3)

• Azathioprine (AZA) · University Hospital Schleswig-Holstein · Immunology
  Azathioprine is a purine analog prodrug that is converted to 6-mercaptopurine, which inhibits purine synthesis and suppresses T-cell and B-cell proliferation.
• Azathioprine / 6 Mercaptopurine · PIBD-Net · Immunology
  Azathioprine and 6-mercaptopurine are purine analogs that inhibit nucleotide synthesis and suppress T-cell and B-cell proliferation to reduce immune-mediated inflammation.
• addition of azathioprine · Védrines, Philippe, M.D. · Immunology
  Azathioprine is a purine analog that inhibits T-cell and B-cell proliferation by interfering with nucleotide synthesis, thereby suppressing immune responses.