What are Potassium channel opener drugs?

Potassium channel opener drugs are pharmacologic agents that share a common mechanism (typically targeting ATP-sensitive potassium channels). 6 are currently marketed, with 3 more in clinical development.

What are the marketed Potassium channel opener drugs?

Marketed Potassium channel opener drugs include minoxidil 5% solution, Ezogabine/Retigabine IR, KAD-1229, Minoxidil Topical, Minoxidil 5% Topical Solution, KLH-2109.

Potassium channel opener

6 marketed 2 in Phase 3 1 in Phase 2

This page covers all Potassium channel opener drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting ATP-sensitive potassium channels, Kv7 (KCNQ) voltage-gated potassium channels, ATP-sensitive potassium channel (KATP).

Targets

ATP-sensitive potassium channels · Kv7 (KCNQ) voltage-gated potassium channels · ATP-sensitive potassium channel (KATP) · ATP-sensitive potassium channels (KATP) · ATP-sensitive potassium channel · KCNQ1

Marketed (6)

minoxidil 5% solution · Allergan · Dermatology
Minoxidil is a potassium channel opener that increases blood flow to hair follicles and prolongs the anagen (growth) phase of the hair cycle.
Ezogabine/Retigabine IR · GlaxoSmithKline · Neurology
Ezogabine opens voltage-gated potassium channels in neurons, reducing neuronal excitability and seizure activity.
KAD-1229 · Kissei Pharmaceutical Co., Ltd. · Cardiovascular
KAD-1229 is a potassium channel opener that relaxes vascular smooth muscle to reduce blood pressure.
Minoxidil Topical · Dr. dr. Lili Legiawati, SpKK(K) · Dermatology
Minoxidil is a potassium channel opener that increases blood flow to hair follicles and prolongs the anagen (growth) phase of the hair cycle.
Minoxidil 5% Topical Solution · Triple Hair Inc · Dermatology
Minoxidil is a potassium channel opener that increases blood flow to hair follicles and prolongs the anagen (growth) phase of the hair cycle.
KLH-2109 · Kissei Pharmaceutical Co., Ltd. · Cardiovascular
KLH-2109 is a potassium channel opener that relaxes vascular smooth muscle to reduce blood pressure.

Phase 3 pipeline (2)

RSD1235 · Astellas Pharma Inc · Cardiovascular
RSD1235 is a potassium channel opener that suppresses atrial fibrillation by prolonging atrial refractoriness and reducing atrial conduction velocity.
Minoxidil Topical Foam · Eurofarma Laboratorios S.A. · Dermatology
Minoxidil is a potassium channel opener that increases blood flow to hair follicles and prolongs the anagen (growth) phase of the hair cycle.

Phase 2 pipeline (1)

IMR-687 · Cardurion Pharmaceuticals, Inc. · Cardiovascular
Potassium channel opener