Potassium Channel Blocker

This page covers all Potassium Channel Blocker drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Voltage-gated potassium channel, Voltage-gated potassium channels, Voltage-gated potassium channels (Kv channels).

Targets

Voltage-gated potassium channel · Voltage-gated potassium channels · Voltage-gated potassium channels (Kv channels) · Potassium channels · Voltage-gated potassium channels (presynaptic) · Voltage-gated potassium channels (Kv1.4, Kv3.1) · Voltage-gated potassium channels (Kv) · ATP-sensitive potassium channels

Marketed (3)

• Firdapse · Catalyst Pharms · Neuroscience · 400
  Firdapse works by blocking potassium channels in the nervous system, allowing more nerve impulses to be transmitted.
• SR-fampridine · University of Southern Denmark · Neurology
  SR-fampridine is a sustained-release formulation of fampridine that blocks potassium channels in nerve fibers, prolonging action potentials and enhancing nerve conduction.
• Sustained-release oral dalfampridine · Sheba Medical Center · Neurology
  Dalfampridine is a potassium channel blocker that enhances action potential conduction in demyelinated nerve fibers by prolonging the duration of the action potential.

Phase 3 pipeline (7)

• TETA 4HCL (60-<W108) · Orphalan · Cardiovascular
  TETA 4HCL is a tetraethylammonium chloride, a potassium channel blocker.
• TETA 4HCL (W12-60) · Orphalan · Cardiovascular
  TETA 4HCL (W12-60) is a tetraethylammonium chloride, a potassium channel blocker.
• TETA 4HCl formulation · Orphalan · Cardiovascular
  TETA 4HCl formulation is a tetraethylammonium chloride, a potassium channel blocker.
• ,4-diaminopyridine · National Center for Research Resources (NCRR) · Neurology
  3,4-diaminopyridine blocks potassium channels on nerve terminals, prolonging action potentials and increasing acetylcholine release at the neuromuscular junction.
• BIIB041 (Fampridine-SR) · Biogen · Neurology
  Fampridine-SR is a potassium channel blocker that enhances nerve impulse conduction by blocking potassium efflux, thereby improving motor function in patients with multiple sclerosis.
• BIIB041 (fampridine) · Biogen · Neurology
  Fampridine is a potassium channel blocker that enhances nerve impulse conduction by blocking potassium efflux, thereby improving motor function in demyelinating diseases.
• 3,4-diaminopyridine · Oregon Health and Science University · Neurology
  3,4-diaminopyridine blocks potassium channels to prolong action potential duration and increase acetylcholine release at the neuromuscular junction.

Phase 2 pipeline (2)

• Dalfampridine Pill · D'Youville College · Neurology
  Blocks potassium channels to enhance nerve conduction
• Diazoxide Choline Controlled-Release Tablet · Essentialis, Inc. · Cardiovascular
  Potassium channel blocker