Polymyxin antibiotic

This page covers all Polymyxin antibiotic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Bacterial lipopolysaccharides and phospholipids, Bacterial lipopolysaccharide (LPS) and outer membrane, Bacterial lipopolysaccharide and phospholipid membranes.

Targets

Bacterial lipopolysaccharides and phospholipids · Bacterial lipopolysaccharide (LPS) and outer membrane · Bacterial lipopolysaccharide and phospholipid membranes · Bacterial lipopolysaccharide (LPS) and cell membrane · Bacterial lipopolysaccharide (LPS)

Marketed (3)

• Standard Dose Colistin · King Saud Medical City · Infectious Disease
  Colistin disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, causing cell lysis and death.
• High Dose Colistin · King Saud Medical City · Infectious Disease
  Colistin is a polymyxin antibiotic that disrupts bacterial cell membranes by binding to lipopolysaccharides and causing leakage of cellular contents.
• Polymyxin e · Mahmoud I Mostafa · Infectious Disease
  Polymyxin E (colistin) disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, causing cell lysis and death.

Phase 3 pipeline (5)

• polymixin/bacitracin · Vanderbilt University Medical Center · Infectious disease
  Polymyxin B and bacitracin work together to inhibit bacterial cell wall synthesis and disrupt bacterial cell membranes.
• Coly Mycin M Injectable Product · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Infectious Disease
  Colistin (polymyxin E) is a cyclic polypeptide antibiotic that disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, leading to cell lysis and death.
• Colistimethate sodium for injection · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Infectious Disease
  Colistimethate sodium is a prodrug of colistin that disrupts bacterial cell membranes by binding to lipopolysaccharides and phospholipids, leading to cell lysis and death.
• Colistin and saline solution · Hospitales Universitarios Virgen del Rocío · Infectious Disease
  Colistin is a polymyxin antibiotic that disrupts bacterial cell membranes by binding to lipopolysaccharides, causing cell lysis and death in gram-negative bacteria.
• Colistimethate sodium (CMS) · Merck Sharp & Dohme LLC · Infectious Disease
  Colistimethate sodium is a prodrug that is hydrolyzed to colistin, which disrupts bacterial cell membranes by binding to lipopolysaccharides and causing cell lysis.