Photosensitizing agent

This page covers all Photosensitizing agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Lipoprotein receptors on neovascular endothelial cells, Protoporphyrin IX (via aminolevulinic acid pathway), Protoporphyrin IX (via aminolaevulinic acid pathway).

Targets

Lipoprotein receptors on neovascular endothelial cells · Protoporphyrin IX (via aminolevulinic acid pathway) · Protoporphyrin IX (via aminolaevulinic acid pathway) · Protoporphyrin IX (photodynamic therapy precursor) · Lipoprotein and abnormal vasculature (non-selective)

Marketed (6)

• Verteporfin Photodynamic Therapy · Novartis · Ophthalmology
  Verteporfin is a photosensitizing agent that accumulates in abnormal blood vessels and, when activated by light, generates reactive oxygen species to destroy those vessels.
• MAL · Photocure · Oncology
  MAL (methyl aminolevulinate) is a photosensitizing prodrug that accumulates in abnormal cells and generates reactive oxygen species when activated by red light, destroying target tissue.
• Methyl Aminolaevulinate 16% Cream · Galderma R&D · Dermatology
  Methyl aminolaevulinate is a photosensitizing prodrug that accumulates in abnormal skin cells and generates reactive oxygen species when activated by red light, destroying target lesions.
• Levulan® Kerastick® · Medical Dermatology Specialists · Dermatology
  Levulan (aminolevulinic acid) is a photosensitizing agent that accumulates in skin lesions and generates reactive oxygen species when activated by blue light, destroying abnormal cells.
• Verteporfin for injection · Novartis · Ophthalmology
  Verteporfin is a photosensitizing agent that accumulates in abnormal blood vessels and, when activated by light, generates reactive oxygen species to destroy those vessels.
• verteporfin PDT · QLT Inc. · Ophthalmology
  Verteporfin is a photosensitizing agent that accumulates in abnormal blood vessels and is activated by light to generate reactive oxygen species that destroy those vessels.

Phase 3 pipeline (4)

• Metvix cream · Galderma R&D · Dermatology/Oncology
  Metvix (methyl aminolevulinate) is a photosensitizing agent that accumulates in abnormal cells and generates reactive oxygen species when activated by light, destroying target lesions.
• Visudyne for injection · QLT Inc. · Ophthalmology
  Visudyne (verteporfin) is a photosensitizing agent that accumulates in abnormal blood vessels and is activated by light to produce reactive oxygen species that destroy those vessels.
• Metvix and natural daylight PDT · Galderma R&D · Oncology/Dermatology
  Metvix (methyl aminolevulinate) is a photosensitizing agent that accumulates in abnormal skin cells and is activated by natural daylight to generate reactive oxygen species that destroy lesions.
• Metvix and conventional PDT · Galderma R&D · Oncology / Dermatology
  Metvix is a photosensitizing agent that accumulates in abnormal skin cells and, when activated by light in photodynamic therapy (PDT), generates reactive oxygen species to destroy lesions.