What are Phosphate Binder drugs?

Phosphate Binder drugs are pharmacologic agents that share a common mechanism (typically targeting Dietary phosphate (non-receptor mechanism)). 3 are currently marketed, with 5 more in clinical development.

What are the marketed Phosphate Binder drugs?

Marketed Phosphate Binder drugs include Renvela, Lanthanum Carbonate Chewable Tablet, Sucroferric Oxyhydroxide Chewable Tablet.

Phosphate Binder

3 marketed 5 in Phase 3

This page covers all Phosphate Binder drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Dietary phosphate (non-receptor mechanism), Dietary phosphate (non-receptor target), Dietary and secreted phosphate (non-selective binding).

Targets

Dietary phosphate (non-receptor mechanism) · Dietary phosphate (non-receptor target) · Dietary and secreted phosphate (non-selective binding)

Marketed (3)

Renvela · Sanofi · Hematology
Renvela works by binding to dietary phosphate in the gut, preventing its absorption into the bloodstream.
Lanthanum Carbonate Chewable Tablet · SIGA Technologies · Nephrology
Lanthanum carbonate binds to phosphate in the gastrointestinal tract, forming insoluble complexes that are eliminated in feces, thereby reducing serum phosphate levels.
Sucroferric Oxyhydroxide Chewable Tablet · University of Colorado, Denver · Nephrology
Sucroferric oxyhydroxide binds phosphate in the gastrointestinal tract to reduce serum phosphate levels in patients with chronic kidney disease.

Phase 3 pipeline (5)

Sevelamer Carbonate (GZ419831) · Sanofi · Nephrology
Sevelamer carbonate is a phosphate binder that works by binding to phosphate in the gastrointestinal tract and preventing its absorption into the bloodstream.
Ferric Citrate 1 GM Oral Tablet [AURYXIA] · USRC Kidney Research · Nephrology
Ferric citrate binds phosphate in the gastrointestinal tract to reduce serum phosphate levels in patients with chronic kidney disease.
Calcium acetate (PhosLo® ) · Genzyme, a Sanofi Company · Nephrology
Calcium acetate binds to dietary phosphate in the gastrointestinal tract to reduce serum phosphate levels in patients with hyperphosphatemia.
Fosrenol (Lanthanum Carbonate) · Shire · Nephrology
Lanthanum carbonate binds to phosphate in the gastrointestinal tract, forming insoluble complexes that are eliminated in feces, thereby reducing serum phosphate levels.
MCI-196 · Tanabe Pharma Corporation · Nephrology / Chronic Kidney Disease
MCI-196 is a phosphate binder that reduces serum phosphate levels by binding phosphate in the gastrointestinal tract.