PDE5 inhibitor

This page covers all PDE5 inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, Multidrug resistance-associated protein 5, Phosphodiesterase type 5 (PDE5), PDE5 (phosphodiesterase type 5).

Targets

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, Multidrug resistance-associated protein 5 · Phosphodiesterase type 5 (PDE5) · PDE5 (phosphodiesterase type 5) · PDE5 (phosphodiesterase 5) · PDE5

Marketed (2)

• Viagra · Pfizer Inc. · Cardiovascular
  Selectively inhibits phosphodiesterase type 5 (PDE5), increasing cGMP levels to relax smooth muscle in the corpus cavernosum and pulmonary vasculature.
• Revatio · Pfizer Inc. · Cardiovascular
  Sildenafil inhibits phosphodiesterase type 5 (PDE5), increasing cGMP levels and enabling penile smooth muscle relaxation.

Phase 3 pipeline (5)

• DA-8159 (Udenafil) · Dong-A Pharmaceutical Co., Ltd. · Urology
  DA-8159 (Udenafil) inhibits phosphodiesterase type 5 (PDE5), increasing cyclic GMP levels to promote smooth muscle relaxation and improve blood flow.
• PDE5 inhibitor (tadalafil) · Regina Elena Cancer Institute · Oncology
  Tadalafil inhibits phosphodiesterase type 5 (PDE5), increasing cyclic GMP levels to promote vasodilation and smooth muscle relaxation.
• DA-5212 · Dong-A ST Co., Ltd. · Cardiovascular / Regenerative Medicine
  DA-5212 is a selective inhibitor of phosphodiesterase 5 (PDE5) that enhances nitric oxide signaling to improve blood flow and tissue perfusion.
• iv sildenafil · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · Urology
  Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that works by increasing blood flow to the penis to treat erectile dysfunction.
• placebo (tadalafil) · Eli Lilly and Company · Urology
  Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor, which works by increasing blood flow to the penis to treat erectile dysfunction.