Nitrofuran antibiotic

This page covers all Nitrofuran antibiotic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Bacterial DNA and ribosomal proteins (non-specific after activation), Bacterial DNA and RNA synthesis; bacterial nitroreductase.

Targets

Bacterial DNA and ribosomal proteins (non-specific after activation) · Bacterial DNA and RNA synthesis; bacterial nitroreductase

Marketed (1)

• nitrofurantoin monohydrate/macrocrystalline capsules · University of California, San Diego · Infectious Disease
  Nitrofurantoin is reduced by bacterial enzymes to reactive intermediates that damage bacterial DNA and proteins, leading to cell death.

Phase 3 pipeline (1)

• Oral nitrofurantoin monohydrate/macrocrystals · NICHD Global Network for Women's and Children's Health · Infectious Disease
  Nitrofurantoin inhibits bacterial DNA and RNA synthesis by interfering with bacterial enzyme systems, making it bactericidal against susceptible urinary tract pathogens.