Immunoglobulin replacement therapy

This page covers all Immunoglobulin replacement therapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting IgM antibodies; complement system (C1q), Polyclonal IgG (multiple epitopes), Multiple pathogenic antigens and pathogens (non-specific).

Targets

IgM antibodies; complement system (C1q) · Polyclonal IgG (multiple epitopes) · Multiple pathogenic antigens and pathogens (non-specific) · Fc receptors and complement system (via IgG antibodies) · Polyclonal human IgG · Fc receptors, complement system, pathogenic antigens · Fc receptors and complement system (via pooled human IgG) · IgG (Immunoglobulin G)

Marketed (4)

• IgM rich Immunoglobin · Sir Takhtasinhji General Hospital · Immunology
  IgM-rich immunoglobulin provides passive immune support by supplying IgM antibodies to enhance complement activation and opsonization of pathogens.
• IgPro20 · CSL Behring · Immunology
  IgPro20 is a subcutaneous immunoglobulin replacement therapy that provides passive immunity by delivering polyclonal human immunoglobulins to patients with primary immunodeficiency.
• Immune Globulin (Human) · Grifols Therapeutics LLC · Immunology
  Immune Globulin (Human) provides passive immunization by supplying pooled human antibodies to enhance immune function and neutralize pathogens.
• Cuvitru 20 % Injectable Solution · University of Edinburgh · Immunology
  Cuvitru is a human immunoglobulin (antibody) replacement therapy that provides passive immunity by supplying functional antibodies to patients with primary immunodeficiency.

Phase 3 pipeline (5)

• IgPro20 (high dose) · CSL Behring · Immunology
  IgPro20 is a subcutaneous immunoglobulin replacement therapy that provides passive immunity by delivering polyclonal human immunoglobulins to treat primary immunodeficiency.
• IV treatment with IGSC, 10% · Baxalta now part of Shire · Immunology
  IGSC 10% is an intravenous immunoglobulin (IVIG) preparation that provides passive immunity by supplying pooled human antibodies to help regulate immune function and fight infections.
• IVIG-PEG · Grifols Therapeutics LLC · Immunology
  IVIG-PEG is a polyethylene glycol-conjugated intravenous immunoglobulin that provides passive immune protection by delivering pooled human antibodies with extended half-life.
• BP-SCIG 20% · Biopharma Plasma LLC · Immunology
  BP-SCIG 20% is a subcutaneous immunoglobulin replacement therapy that provides passive immunity by delivering immunoglobulin G (IgG) antibodies to patients with primary immunodeficiency.
• IgPro20 (low dose) · CSL Behring · Immunology
  IgPro20 is a subcutaneous immunoglobulin replacement therapy that provides passive immunity by delivering polyclonal human immunoglobulins to patients with primary immunodeficiency.