What are Growth factor drugs?

Growth factor drugs are pharmacologic agents that share a common mechanism (typically targeting EGFR (Epidermal Growth Factor Receptor)). 5 are currently marketed, with 10 more in clinical development.

What are the marketed Growth factor drugs?

Marketed Growth factor drugs include epidermal growth factor, fibroblast growth factor, ReGen-GF, early leukostim, late leukostim.

Growth factor

5 marketed 7 in Phase 3 3 in Phase 2

This page covers all Growth factor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting EGFR (Epidermal Growth Factor Receptor), Fibroblast growth factor receptor (FGFR), GF.

Targets

EGFR (Epidermal Growth Factor Receptor) · Fibroblast growth factor receptor (FGFR) · GF · G-CSF receptor · PDGF-BB · ErbB4 · PDGF receptor (PDGFR) · FGF-2 · KGF receptor · EGF receptor

Marketed (5)

epidermal growth factor · Chinese PLA General Hospital · Dermatology, Wound Healing, Tissue Repair
Epidermal growth factor (EGF) binds to and activates the epidermal growth factor receptor (EGFR) on cell surfaces, promoting cell proliferation, differentiation, and survival.
fibroblast growth factor · Chinese PLA General Hospital · Regenerative Medicine / Wound Care
Fibroblast growth factor (FGF) promotes cell proliferation, differentiation, and angiogenesis by binding to FGF receptors on target cells.
ReGen-GF · Austin Institute for Clinical Research · Wound healing
ReGen-GF is a recombinant human growth factor that promotes tissue regeneration and repair.
early leukostim · Hyuk moon Kim · Oncology
Early leukostim stimulates the production of white blood cells.
late leukostim · Hyuk moon Kim · Oncology
Late leukostim stimulates the proliferation of hematopoietic progenitor cells.

Phase 3 pipeline (7)

SGX942 · Soligenix · Wound healing
SGX942 is a recombinant human platelet-derived growth factor isoform BB (PDGF-BB) used to promote wound healing.
Pegylated G-CSF · Australasian Gastro-Intestinal Trials Group · Oncology
Pegylated G-CSF stimulates the production of white blood cells, specifically neutrophils, to help the body fight infection.
Recombinant human Neuregulin for injection · Zensun Sci. & Tech. Co., Ltd. · Cardiovascular
Recombinant human Neuregulin for injection is a growth factor that promotes cardiac repair and regeneration.
RhEGF · SVS Institute of Dental Sciences · Dentistry / Periodontal / Oral Surgery
RhEGF is a recombinant human epidermal growth factor that promotes tissue regeneration and wound healing in oral and dental tissues.
rhG-CSF/PEG-rhG-CSF · Xiamen Amoytop Biotech Co., Ltd. · Oncology
rhG-CSF/PEG-rhG-CSF stimulates the production of white blood cells.
BioChaperone PDGF-BB · Adocia · Wound Care / Regenerative Medicine
BioChaperone PDGF-BB is a formulation of platelet-derived growth factor BB designed to enhance wound healing and tissue repair by promoting angiogenesis and cell proliferation.
Trafermin 0.01% spray · Olympus Biotech Corporation · Wound healing
Trafermin is a recombinant human fibroblast growth factor 2 (FGF-2) used to promote wound healing.

Phase 2 pipeline (3)

CPK dosage · Centre Oscar Lambret · Oncology
CPK is a recombinant human keratinocyte growth factor used to stimulate epithelial regeneration.
ABX-EGF · Amgen · Wound healing
ABX-EGF is a recombinant human heparin-binding EGF-like growth factor.
G-CSF and plerixafor · Genzyme, a Sanofi Company · Oncology
Stimulates the production of neutrophils by binding to the G-CSF receptor