What are Glucokinase activator drugs?

Glucokinase activator drugs are pharmacologic agents that share a common mechanism (typically targeting Glucokinase (GCK)). 0 are currently marketed, with 6 more in clinical development.

Glucokinase activator

0 marketed 5 in Phase 3 1 in Phase 1

This page covers all Glucokinase activator drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Glucokinase (GCK), Glucokinase.

Targets

Glucokinase (GCK) · Glucokinase

Phase 3 pipeline (5)

AZD0585 · AstraZeneca · Diabetes
AZD0585 is a selective activator of the glucokinase enzyme that enhances glucose sensing and insulin secretion in pancreatic beta cells.
GK567 · Galderma R&D · Endocrinology / Diabetes
GK567 is a glucokinase activator that enhances glucose metabolism in pancreatic beta cells to stimulate insulin secretion.
HMS5552 · Hua Medicine Limited · Diabetes
HMS5552 is a glucokinase activator that enhances glucose sensing and insulin secretion in pancreatic beta cells.
Placebo to MK-8527 · Merck Sharp & Dohme LLC · Diabetes
MK-8527 is a glucokinase activator that enhances glucose sensing and insulin secretion in pancreatic beta cells.
MK-6072 · Merck Sharp & Dohme LLC · Diabetes
MK-6072 is a glucokinase activator that enhances glucose sensing and insulin secretion in pancreatic beta cells.

Phase 1 pipeline (1)

ARRY-403, glucokinase activator; oral · Array BioPharma · Diabetes
Glucokinase activator