What are cytokine drugs?

cytokine drugs are pharmacologic agents that share a common mechanism (typically targeting GM-CSF receptor). 3 are currently marketed, with 6 more in clinical development.

What are the marketed cytokine drugs?

Marketed cytokine drugs include Gm-Csf, IL-2 (interleukin 2), Interleukin-3.

cytokine

3 marketed 4 in Phase 3 2 in Phase 2

This page covers all cytokine drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting GM-CSF receptor, IL-2 receptor (IL-2R), IL-3 receptor (CD123).

Targets

GM-CSF receptor · IL-2 receptor (IL-2R) · IL-3 receptor (CD123) · Interferon-gamma receptor (IFNGR) · IFNGR · GM-CSF receptor (CD116/CD131) · CSF-1 receptor (c-FMS) · Interleukin-2 receptor

Marketed (3)

Gm-Csf · Pfizer · Oncology
IL-2 (interleukin 2) · King's College London · Oncology, Immunology
IL-2 binds to IL-2 receptors on T cells and NK cells, promoting their proliferation, activation, and differentiation to enhance anti-tumor immune responses.
Interleukin-3 · Sandoz · Hematology/Oncology
Interleukin-3 is a cytokine that stimulates the proliferation and differentiation of hematopoietic stem cells and progenitor cells, promoting the production of multiple blood cell lineages.

Phase 3 pipeline (4)

Interferon-gamma, Recombinant · Radboud University Medical Center · Immunology
Recombinant interferon-gamma activates macrophages and enhances immune cell function to boost the body's antiviral and antimicrobial defenses.
interferon γ-1b · Amgen · Immunology
Interferon γ-1b enhances immune responses by activating macrophages and natural killer cells, and it also has antiviral properties.
GM-CSF group · Centre for Endocrinology and Reproductive Medicine, Italy · Oncology
GM-CSF (granulocyte-macrophage colony-stimulating factor) stimulates the production and activation of granulocytes and macrophages to enhance immune response.
CSF-1 · Orasis Pharmaceuticals Ltd. · Immunology
CSF-1 is a recombinant human colony-stimulating factor 1 that promotes the growth and differentiation of myeloid progenitor cells.

Phase 2 pipeline (2)

Dose D1 of interleukin-2 · Assistance Publique - Hôpitaux de Paris · Oncology
Interleukin-2 stimulates T-cell proliferation and activation.
Dose D3 of interleukin-2 · Assistance Publique - Hôpitaux de Paris · Oncology
Interleukin-2 stimulates T-cell proliferation and activation.